Research Ethics Oversight for Multi-jurisdictional Clinical Trials in Canada: A Historical Perspective to Inform Future Direction

Authors

  • Brenda Lucas Canadian Critical Care Trials Group and the Network of Clinical Trials Networks, Toronto, Ontario, Canada https://orcid.org/0009-0005-7262-2356
  • Jaime Flamenbaum Science Policy Branch, Canadian Institutes of Health Research, Ottawa, Ontario, Canada https://orcid.org/0000-0002-8473-5551
  • Holly Longstaff Research Integration & Innovation, PHSA Research and Academic Services; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada https://orcid.org/0000-0002-1662-0832
  • Srinivas Murthy Department of Pediatrics, BC Children’s Hospital Research Institute, Vancouver, British Columbia, Canada https://orcid.org/0000-0002-9476-839X
  • Brittney Schichter Research Integration & Innovation, PHSA Research and Academic Services, Vancouver, British Columbia, Canada https://orcid.org/0009-0000-3603-0744

DOI:

https://doi.org/10.7202/1112276ar

Keywords:

research ethics, pan-Canadian, harmonization, clinical trials

Language(s):

English

Abstract

As a condition of funding from the Canadian Tri-Agencies, researchers and institutions are expected to adhere to the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans (TCPS) and research projects must obtain approval from a Research Ethics Board (REB). Yet there are a limited number of frameworks and standards to guide the conduct and decisions of REBs in Canada and these are most often voluntary. Delays and increased costs resulting from the lack of a common or coordinated approach to REB review for multi-jurisdictional clinical trials is a long-standing issue in the Canadian research environment. Formal reviews and recommendations as early as 2006 call for accreditation or qualification for REBs, use of common forms and templates, and federal leadership to harmonize processes.

(c) Han Han Li

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Published

2024-06-21

How to Cite

[1]
Lucas B, Flamenbaum J, Longstaff H, Murthy S, Schichter B. Research Ethics Oversight for Multi-jurisdictional Clinical Trials in Canada: A Historical Perspective to Inform Future Direction. Can. J. Bioeth 2024;7:23-32. https://doi.org/10.7202/1112276ar.

Issue

Vol. 7 No. 2-3 (2024): Open Issue & CBS Workshops

Section

Articles

License

Copyright (c) 2024 Brenda Lucas, Jaime Flamenbaum, Holly Longstaff, Srinivas Murthy, Brittney Schichter

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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